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(V1725) |
Increased early sodium current provokes familial atrial fibrillation and reduces effectiveness of sodium channel block |
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L. Sommerfeld, M. O'Reilly, C. O'Shea, S. Broadway-Stringer, S. Andaleeb, J. S. Reyat, S. N. Kabir, A. Malinova, D. Delbue, D. Stastny, L. Fortmüller, K. Gehmlich, D. Pavlovic, B. Skryabin, A. P. Holmes, P. Kirchhof, L. Fabritz (Hamburg, Münster; Birmingham, UK) |
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Diskussion |
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(V1726) |
Chronic deprivation and substitution of androgens modulates arrhythmogenicity and NaV1.5 expression in a SCN5A loss-of-function mouse model |
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M. Kruska, T. Fink, P. Yampolsky, L. Fabritz, P. Kirchhof, D. Thomas, H. A. Katus, N. Frey, M. Koenen, P. Schweizer (Mannheim, Bad Oeynhausen, Heidelberg, Hamburg; Birmingham, UK) |
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Diskussion |
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(V1727) |
Selective inhibition of NaV1.8 reduces diastolic Ca leak and atrial arrhythmias in patients with sleep-disordered breathing |
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R. Hultsch, P. Hegner, S. Lebek, M. Tafelmeier, Z. Provaznik, D. Camboni, C. Schmid, L. S. Maier, S. T. Sossalla, M. Arzt, S. Wagner (Regensburg) |
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Diskussion |
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(V1728) |
Inactivation of HDAC2 attenuates atrial remodeling and delays onset of atrial fibrillation in CREM-IbΔC-X transgenic mice, a mouse model of spontaneous onset atrial fibrillation |
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J. S. Schulte, L. B. Tardio, J. P. Reinhardt, M. D. Seidl, U. Kirchhefer, F. U. Müller (Münster) |
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Diskussion |
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(V1729) |
Mechanistic insights of the p.L13R mutation in the nuclear envelope protein LEMD2 and its role in the development of cardiomyopathy |
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R. Chen, A. Kroth, A. P. Arias Loza, G. Grüner, M. Kohlhaas, N. Wagner, A. Cirnu, T. Williams, C. Maack, B. Gerull (Würzburg) |
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Diskussion |
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(V1730) |
Increased ox-CaMKII-dependent pro-arrhythmic activity in an obstructive sleep apnea mouse model |
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M. Gugg, P. Hegner, S. Lebek, L. S. Maier, M. Arzt, S. Wagner (Regensburg) |
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Diskussion |