P87	Transplantation of bone marrow derived progenitor cells in acute myocardial infarction. The first results.
1R.Pudil, 1J.Vojacek, 2S.Filip, 3P.Mericka, 1J.Mokry, 1J.Stasek, 1J.Dominik, 1J.Maly, 1M.Solar, 4D.Vokurkova
1Charles University Prague, Faculty of Medicine,, Hradec Kralove, CZ; 2Department of Oncology and Radiology, University Hospital, Hradec Kralove, CZ; 3Tissue Centre, University Hospital, Hradec Kralove, CZ; 4Department of Clinical Immunology and Allergology, University Hospital, Hradec Kralove, CZ.

Financial support by the cardiovascular research project of the Charles University Prague MSM 0021620817 The intracoronary administration of autologous bone marrow cells (BMCs) has been shown to improve the left ventricle function in the course of acute myocardial infarction. Therefore we have started a clinical trial using transplantation of BMCs in the acute phase of myocardial infarction. The aim of our study is to assess the feasibility and safety of this procedure, and effect on the left ventricle function of these patients. We describe the first experience in three patients with acute myocardial infarction reperfused using direct stenting. The aspiration of bone marrow from the sternum provided sufficient amount of the cells for transplantation. No serious ischemia and no changes in coronary artery patency were detected after intracoronary infusion. The left ventricle ejection fraction was increasing throughout the time of three-month follow-up. No other complications (ventricular arrhythmias, reinfarction, thrombus formation) were detected.

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