P247	Familial predisposition to hypertension and microvascular vasomotion.
B.Gryglewska, M.Nêcki, T.Grodzicki
Department of Internal Medicine and Gerontology, Jagiellonian University, Kraków, PL.

Objective: To test the hypothesis that vasomotion is disturbed in subjects with familial predisposition to hypertension (HT). Design and Methods: Using the laser Doppler flowmetry (Periflux 5001, Perimed, Sweden) we measured rest blood flow on the forearm skin in three groups of subjects: I - with no predisposition to HT, II- with familial predisposition to HT and normal blood pressure (BP) and III-with predisposition and increased BP. Conventional blood pressure measurements (three times, last two were used to determine blood pressure level) and ambulatory blood pressure monitoring (ABPM, SpaceLabs 90207) were performed. Rest blood flow was recorded for 3 minutes after 10 minutes subjects resting in a warm, quiet room. Fast Fourier transformation was performed to provide the frequency power spectrum of each recording. We analyzed the power (arbitrary units, AU) of three frequency intervals of oscillations: <0,03Hz (metabolism of the perfused tissue), 0,03-0,15Hz (sympathetic and myogenic activity) and 0,15-0,5Hz (parasympathetic and respiratory rhythms). Means (±SD)were compared with t-test. Results: The studied groups were slightly differed with respect to age (27,0±8,8 vs 33,9±9,6 vs 34,4±8,6 years, respectively). BP values both conventional and ABPM were significantly higher (p<0,001) in the hypertensive group (III) than the others (conventional measurements: 119,9±9,1/77,3±6,6 vs 121,7±7,6/76,1±7,0 vs 152,8±8,3/95,2±7,1 mmHg, ABPM: 118,0±11,0/72,5±8,7 vs 118,4±8,9/74,3±6,8 vs 131,7±10,3/82,4±9,3 mmHg, respectively). Frequency power I (n=32) II (n=27) III (n=29) <0,03Hz (AU) 0,68 ± 0,5 0,61 ± 0,6 0,58 ± 0,5 0,03-0,15Hz (AU) 0,38 ± 0,2 0,27 ± 0,2 0,28 ± 0,2 0,15-0,5Hz (AU) 0,08 ± 0,04 0,08 ± 0,06 0,09 ± 0,12 Power ratio 0,03-0,15/0,15-0,5 4,58 ± 1,9 3,08 ± 1,2*** vs I 3,5 ± 1,5* vs I Conclusions: Vasomotion disturbances of peripheral microcirculation may present early changes of prehypertensive persons with familial predisposition to hypertension.

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