P176	Brachial artery reactivity in patients with impaired glucose tolerance and proteinuria.
R.Jimenez, T.Olivar, J.Beltran, for The Heart Institute of St. Luke's Medical Center
Heart Institute, St. Luke's Medical Center, Quezon City, PH.

Background. Endothelial dysfunction has shown to predict cardiovascular morbidity and it happens early in the atherosclerotic disease process. In individuals at risk of developing type 2 diabetes, abnormalities in vascular reactivity and biochemical markers of endothelial cell activation are present early even at a stage when normal glucose tolerance exists. Urinary albumin excretion and endothelial dysfunction has been strongly and independently associated with increased cardiovascular events in the general population and in patients with diabetes mellitus (DM) type 2. However, it is not known how early these abnormalities can be detected in the prediabetic stage. Objective. The aim of this study was to investigate the relation between proteinuria and endothelial dysfunction as measured by brachial artery reactivity (BAR) in patients with impaired glucose tolerance (IGT). Methods. Medical records were used to review 83 patients (48 male, mean age of 61.47 ± 17.56) who were diagnosed with IGT on routine medical check-up at St. Lukes Medical Center. They were then categorized according to presence or absence of proteinuria (qualitative assessment). Ultrasound BAR testing was used to measure endothelium-dependent vasodilation (EDV). Results. Patients with proteinuria and without proteinuria have no significant difference with regard to baseline characteristics except that proteinuric patients have higher BMI (p=0.000). EDV responses were significantly lesser in patients with proteinuria than those without (p=0.037). Age, smoking, BMI, 2-hour GTT, and triglycerides were found to be significant predictors of EDV together with proteinuria. Among the variables, only BMI is positively correlated. For every unit increase in BMI, there is a corresponding 0.911% increase in EDV. Conclusion. In patients with IGT, the presence of proteinuria is associated with impaired endothelial function. Keywords: albuminuria, brachial artery reactivity, endothelium-dependent vasodailation, endothelial dysfunction, impaired glucose tolerance, proteinuria,

Copyright © 2005 S. Karger AG, Basel. Any further use of this abstract requires written permission from the publisher.