J. Vasc. Biol. 42, Sup:2 (2005) pp85-86

P246 Association of the G-protein β3 subunit gene polymorphism with hypertension and vascular hypertrophy.
1E.Velittchenko, 1A.Avtandilov, 2G.Ryabov, 2A.Bobkov
1Russian Academy of Advanced Medical Studies, Moscow, RU; 2The D.I. Ivanovsky Institute of Virology, Moscow, RU.

Association of the G protein ß3 subunit (GNB3) gene polymorphism with hypertension was shown recently. To evaluate an association of this polymorphism with hypertension and cardiovascular remodeling we determined the frequency of GNB3 825T allele in a cohort of individuals with strong family history of hypertension.

Methods.156 subjects were included in the study and divided into 3 groups: 1) young normotensive subjects, 2) young hypertensive subjects and 3)hypertensive parents.

Characteristics of the groups
  group 1 group 2 group 3
Age,years 20.4±2.5 20.8±2.7 48.7±4.2
Family history of hypertension + + +
Hypertension - + +
T allele frequency 0.25 0.37 0.40
TT/TC/CC ,% -/50/50 11/51/38 12/54/34


All patients were subjected to echocardiography, vessels ultrasound examination and PCR and RFLP analyses. After genotyping the patients were divided into 2 subgroups: T-allele carriers and C-homozygous patients.

Results.The frequency of the 825T allele in the groups of hypertensives was significantly higher in comparison to the group of patients without blood pressure elevation. There were no TT-genotypes in the group 1, furthermore the frequency of CC-gomozygous patients in this group was significantly higher in comparison to the groups 2 and 3. The presence of T-allele was associated with radial artery hypertrophy in all groups.Vascular resistance was also significantly higher in T-allele carriers. No association between genotypes and carotid artery intima-media thickness or left ventricular hypertrophy was observed.




GNB3 C825T and radial artery hypertrophy

Conclusion.The data presented suggest an associatin of GNB3 C825T polymorphism with hypertension and radial artery hypertrophy.

Copyright © 2005 S. Karger AG, Basel. Any further use of this abstract requires written permission from the publisher.