Clin Res Cardiol (2023). https://doi.org/10.1007/s00392-023-02180-w |
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Serum levels of the endoplasmic-reticulum-stress chaperone GRP78 are associated with inflammation, identify patients with coronary artery disease and predict mortality | ||
M. Al Zaidi1, E. Repges1, S. Sommer-Weisel1, F. Jansen1, S. Zimmer1, V. Tiyerili2, G. Nickenig1, A. Aksoy1 | ||
1Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn; 2Klinik für Innere Medizin I, Kath. St. Paulus Gesellschaft, Dortmund; | ||
Introduction: Here, we investigated the significance of serum GRP78 in patients undergoing coronary angiography for suspected CAD.
We further compared GRP78 levels to other biomarkers including WBC, Hemoglobin, Troponin, Creatinine, and Interleukin-6. There was no association between GRP78 levels and the mentioned biomarkers, except for a positive correlation between GRP78 and levels of Interleukin-6 (Pearson r =0.14, p = 0.004). GRP78 levels were increased in patients with CAD when compared to patients without CAD (2640 ng/ml [95% CI: 2415-2864] vs. 2178 ng/ml [95% CI: 1893-2463], p = 0.013). Interestingly, GRP78 levels were lower in patients with ACS than in patients with CCS (2284 ng/ml [95% CI: 1944-2642] vs. 2822 [95% CI: 2531-3113], p = 0.018). There was no difference between NSTEMI and STEMI patients. Finally, we assessed prognostic relevance of GRP78 in patients with CAD. Intriguingly, increased GRP78 levels were associated with lower occurrence of the clinical endpoint of one-year mortality (5.3% vs. 10.6 % vs. p = 0.016). Increased GRP78 levels were associated with reduced one-year mortality in both continuous (HR: 0.48 [95% CI: 0.25 - 0.92]) and categorial analyses stratified by median GRP78 (HR 0.54 [0.28 – 0.98]). After adjusting for Interleukin-6, age, sex, BMI, diabetes, CKD, and presentation as ACS, GRP78 remained an independent predictor of one-year mortality in patients with CAD.
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https://dgk.org/kongress_programme/jt2023/aV427.html |