Clin Res Cardiol (2023). https://doi.org/10.1007/s00392-023-02180-w |
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New treatment concept for ICD patients with first appropriate ICD shock is associated with better outcome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
T. Kleemann1, E. Lampropoulou1, K. Kouraki1, M. Strauß1, O. Mohammad1, A.-R. Wenz1, R. Zahn1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1Medizinische Klinik B, Klinikum der Stadt Ludwigshafen gGmbH, Ludwigshafen am Rhein; | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Introduction:
Patients with implantable cardioverter defibrillator (ICD) receiving appropriate
ICD-shocks are known to have a worse prognosis. We recently developed a new
treatment concept for ICD-patients with appropriate ICD shock, the ToVAMI
protocol, which consists of the following three steps: Trigger optimization,
Ventricular Arrhythmia treatment and Medical and Interventional
prognostic heart failure treatment. This protocol was implemented into clinical
practice since 9/2018. Aim of the study was to evaluate the impact of
the ToVAMI protocol on the outcome of patients with first appropriate ICD
shock. Methods and Results: A total
of 255 consecutive patients of a prospective single-centre ICD-registry who
received a first appropriate ICD shock between 2012 and 8/2022 were analyzed.
Patients with first ICD shock between 2012 and 8/2018 (control group, n = 175)
were compared with patients with first ICD shock between 9/2018 and 6/2021 who
were treated according to the ToVAMI protocol (ToVAMI group n = 80). Prospective
use of the ToVAMI approach increased the rate of identified triggers (42% vs.
60%), VA therapy (34% vs. 51%), and tripled the rate of optimised heart failure
treatment. Patients treated according to
the ToVAMI protocol had better survival without recurrent ICD shock (73% versus
55% at two years, p = 0.02) (Figure 1). This was mainly due to a decrease in recurrent
ICD-shocks from 48% to 25% at two years (p = 0.01), while all-cause mortality
showed only a trend towards lower mortality at two years (19% versus 10%, p =
0.32). In a multivariate analysis adjusting for 10 parameters, the ToVAMI approach
was independently associated with a lower combined endpoint of mortality and repeated
ICD shocks. Conclusion: The use of
ToVAMI in patients with first ICD shock is associated with a reduction of the
combined endpoint of mortality and recurrence of appropriate ICD shocks. Table 1. Clinical characteristics of patients at first ICD shock
Figure 1 |
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https://dgk.org/kongress_programme/jt2023/aV1097.html |