Clin Res Cardiol (2022). https://doi.org/10.1007/s00392-022-02002-5
Impact of peripheral angioplasty on wound oxygenation measured with near-infrared spectroscopy in patients with critical limb ischemia
R. J. Foerster1, M. Stern1, Y. Heinen1, S. Baasen1, J. Schremmer1, R. Sansone1, C. Heiss2, M. Kelm1, H. L. Busch1
1Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf, Düsseldorf; 2Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK;

Background: Up today, Near-infrared Spectroscopy (NIRS) has been proposed as a promising noninvasive tool for the assessment of hemoglobin oxygen saturation (StO2) in complex wounds in patients with critical limb ischemia (CLI). 

 

Objective: Our aim was to evaluate the potential of NIRS to measure capillary oxygen saturation and microcirculation not only near the wound but also directly in the wound.

Methods: We included 34 patients with PAD Rutherford stage 5-6 in this prospective, single center study. StO2 maps in and around the wound were analyzed at baseline one day before and one day after angioplasty using a NIRS camera; macrovascular function was assessed by Doppler ultrasound with spectral analysis including ankle-brachial index (ABI). 

 

Results: We found that baseline StO2 of the wound area was 63% (± 3.66 [SE]) and 34% in the wound (± 4.8 [SE]). One day after angioplasty, wound area StO2 significantly increased to 71% (± 3.09 [SE]; p<0.001) and wound StO2 increased even more pronounced to 42% (± 4,77 [SE]; p<0.0001). Likewise, ABI increased in the treated leg (before 0.74 ± 0.03 [SE]; after 0.87 ± 0.02 [SE]; p = 0.008). 

Conclusion: NIRS seems to be a promising tool to monitor tissue perfusion and wound oxygenation in patients undergoing endovascular treatment. This is the first study to assess oxygenation in the wound using a NIRS camera after peripheral angioplasty.
https://dgk.org/kongress_programme/jt2022/aP880.html