Clin Res Cardiol (2022). https://doi.org/10.1007/s00392-022-02002-5 |
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Predictors of functional decline after 8 months in elderly patients with NSTEMI | ||
C. Stadelmaier1, M. Waliszewski2, T. Kieschnick1, K. Rank1, H. Rittger1 | ||
1Med. Klinik I - Kardiologie, Klinikum Fürth, Fürth; 2Department of Medical Scientific Affairs, B. Braun Group, Berlin; | ||
Background There is currently a paucity of evidence on how to optimally treat elderly patients presenting with non-ST-elevation myocardial infarction (NSTEMI). The EVALUATE-Pilot-Study was designed as a nonrandomized, prospective, single-centre study to evaluate the choice of treatment and 8-months-outcome of patients > 75 years presenting with NSTEMI. Special attention was payed to the functional status, comorbidities and frailty. Methods Consecutive patients ≥ 75 years presenting with NSTEMI to our hospital between 07/17 and 07/18 were included into the EVALUATE-study. Patients were asked to participate and sign informed consent 0 to 2 days after reception. Demographic data, past medical history and present medical condition were documented. During day 0 and day 2 geriatric assessment including clinical frailty scale, Barthel-Index, charlson comorbidity index (CCI), “Timed up and go”-Test (TUG), Mini Mental Status Test, Geriatric depression scale, SF-36 (Quality of life), IADL, Killip-Score, Grace-Score and Euro-Score were performed. After 8 months patients were re-evaluated either within a follow-up stay or by a visit at home. Functional decline was defined as a decrease in Barthel-Index by at least 20 points. Results Of 106 patients (mean age 81.9±5.3, 57% male), 68 pts. (64%) were treated with intervention, 38 pts. (36%) conservatively. Patients treated with intervention were significantly younger (80.9±4.7 vs. 83.5±6.0; p=0.02) and had a lower Killip-Score (1.16±0.37 vs. 1.37±0.63, p=0.05). All other demographic variables as well as cardiovascular risk factors, functional status and laboratory parameters were comparable. Mean Barthel-Index at baseline was 85.9 ± 20.5 and showed no significant difference between patients treated with intervention and conservatively treated patients (88.0±19.9 vs. 82.2±21.4, p=ns). Patients were followed-up after 33±12 (34±14 vs 33±10, p=ns) weeks if alternate endpoints (death, severe cognitive impairment) had not already been reached. 22 patients (21%) were lost to follow-up. Mean Barthel-Index at follow-up was 84.9 ± 23.5. Functional decline was observed in 10 patients (17%). Grace Risk Score (OR 1.04, 95% CI: 1.00-1.08, NR2 0.125, p=0.04), Euro Score (OR 1.53, 95% CI: 1.12-2.23, NR2 0.189, p=0.01), CCI (OR 1.57, 95% CI: 1.15-2.32, NR2 0.223, p=0.01) and TUG (OR 1.14, 95% CI: 1.02-1.30, NR2 0.206, p=0.03) predicted functional decline. Age was no significant predictor of functional decline (OR 1.12, 95% CI: 1.00-1.26, NR20.096, p=ns), Conclusion In this prospective analysis of consecutive patients > 75 years presenting with NSTEMI functional decline was observed in about every fifth patient, thus being a highly relevant problem for this patient collective. Cardiac risk scores (Grace Score, Euro Score), comorbidity burden (CCI) and gait speed (TUG) predicted functional decline. |
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https://dgk.org/kongress_programme/jt2022/aP546.html |