Clin Res Cardiol (2022). https://doi.org/10.1007/s00392-022-02002-5 |
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Single center experience of baroreflex activation therapy in heart failure with reduced ejection fraction. | ||
C. Blanco1, E. B. Winzer1, N. Mangner1, K. M. Sveric1, S. Grimm1, M. Flechsig1, T. Madej2, M. Knaut2, A. Linke1 | ||
1Klinik für Innere Medizin, Kardiologie und Intensivmedizin, Herzzentrum Dresden GmbH an der TU Dresden, Dresden; 2Klinik für Herzchirurgie, Herzzentrum Dresden GmbH an der TU Dresden, Dresden; | ||
Background: In heart failure with reduced ejection fraction (HFrEF) chronic sympathoexcitation and diminished baroreflex sensitivity are associated with higher mortality. Baroreflex activation therapy (BAT) in HFrEF patients was shown to reduce natriuretic peptide levels (NT-proBNP), to increase six minute walking distance, and to improve quality of life, at least in patients with NT-proBNP levels below 1600 pg/mL at baseline. The impact of BAT on heart failure hospitalizations and mortality is currently unknown. Experience with BAT in routine clinical practice is very limited. Methods: We report on patient characteristics and clinical results after 12 months of treatment in a single centre experience of BAT in HFrEF. Due to small numbers, open-label design, and missing control group results are descriptive. Data are reported as absolute numbers and % or median with interquartile range. Results: Since 2014, 30 patients with chronic HFrEF were
treated with BAT (BarostimTM, CVRX Inc., Minneapolis, MN, USA). Median age was 67 (63-77) years, 27 patients (90%) were male, median BMI was 29 (26-35). Eighteen
patients (60%) suffered from ischemic heart disease. Four patients (18%) were
in NYHA class IV at baseline, all others in NYHA class III, 25 patients (83%)
were previously hospitalized due to decompensated heart failure. Renal function
was impaired, eGFR 55 mL/min (34-70). Disease modifying drugs were used
frequently and 10 patients (33%) were treated with Cardiac Resynchronization
Therapy. Median follow-up was
16 (10-33) months. During this time 10 patients died. Mortality at 1 and 3
years was exactly as expected by MAGGIC risk score, and numbers of death/100
pt. years was 16.8, which was comparable to the findings in the placebo group
of the VICTORIA trial (Vericiguat in Patients with Heart Failure and Reduced
Ejection Fraction) with 16.9 death/100 pt. years. VICTORIA included a similar
patient population. However, the number of first and recurrent heart failure
hospitalizations was 28.5/100 pt. years in our cohort, lower than what was
seen in VICTORIA with 40.4 events/100 pt. years. Conclusion: HFrEF patients in this single centre cohort treated with baroreflex activation therapy are clearly in a state of advanced heart failure. BAT was safe in an experienced centre. Results are promising since LV-EF and NYHA class improved after 12 months. NYHA class IV, NT-proBNP levels > 1600 pg/mL, and eGFR < 30 ml/min at baseline are predictors of worse outcome. Further studies are necessary to identify optimal candidates for BAT and clinical impact in HFrEF. |
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https://dgk.org/kongress_programme/jt2022/aP1201.html |