87. Jahrestagung der Deutschen Gesellschaft für Kardiologie

Mittwoch, 7. April 2021 (Posterwalk 2) 12:00-13:00

Postervorträge

Molekulare Basis von Kardiomyopathien

Diskussionsleiter: L. Fabritz (Birmingham, UK), S. Klaassen (Berlin)

(P170) Soluble adenylyl cyclase affects AKT and CaMKII activity in adult rat cardiomyocytes, but not in H9c2 cells. Are H9c2 cells really cardiomyocytelike?
    N. Radev, T. Poppenga, A. Al Haj, H. G. Mannherz, A. Mügge, N. Hamdani, D. Cimiotti, K. Jaquet, für die Studiengruppe: AG13 (Bochum)
(P171)

DGK-Abstract-Preis 2021:
Mechanistic insights of the p.L13R mutation in the nuclear envelope protein LEMD2 and its role in the development of cardiomyopathy

    R. Chen, G. Grüner, A. P. Arias Loza, M. Kohlhaas, A. Nickel, N. Abdelfatah, T. Williams, C. Maack, B. Gerull (Würzburg, 97078; Calgary, CA)
(P172) In-vitro cardiomyocyte differentiation of mouse embryonic stem cells with patient specific LMNA mutation reveals dysregulation of mTOR pathway
    B. Neupane, K. Pradhan, M. Gramlich (Aachen)
(P173) Expression of the TMEM43 Mutation p.S358L in a Transgenic Zebrafish Model Reveals Alterations in Cardiac Morphology and Performance
    M. Zink, A. Seewald, M. C. Nguyen, T. Williams, D. Liedtke, C. Stigloher, S. J. Childs, B. Gerull (Würzburg; Calgary, CA)
(P174) Mechano-energetic uncoupling underlies lack of inotropic reserve in Barth syndrome cardiomyopathy
    J. Schwemmlein, A. Nickel, M. Kohlhaas, M. Hohl, E. Bertero, V. Sequeira, C. Krug, C. Carlein, K. Münker, S. Atighetchi, A. Müller, A. Kazakov, R. Kappl, K. von der Malsburg, M. Böhm, U. Laufs, P. Rehling, J. Dudek, M. van der Laan, L. Prates-Roma, C. Maack (Würzburg, Homburg/Saar, Saarbrücken, Leipzig, Göttingen)
(P175) The RBM20 splicing target CAMK2D causes cardiac dysfunction in RBM20 cardiomyopathy
    M. van den Hoogenhof, M. Dewenter, J. Duran, D. Lennermann, M. Krüger, E. Creemers, J. Backs (Heidelberg, Köln; Amsterdam, NL)
(P176) A novel "loss of function" Myoscape mutation derived from patients with Dilated Cardiomyopathy and Short-QT syndrome affects cardiac output in zebrafish in vivo and hypertrophic gene program in vitro
    B. Völschow, A. Farahvashi, M. Leye, C. Tannert, P. Doldi, N. Frey, M. Eden (Kiel, München, Heidelberg)
(P177) Decoding dilated cardiomyopathy with ataxia (DCMA) using patient-derived and gene-edited human induced pluripotent stem cell (iPSC)-derived cardiomyocytes
    A. Janz, A. Cirnu, M. Leskien, A. Seewald, Y. Ueda, M. Regensburger, M. Kohlhaas, N. Nose, P. Wörsdörfer, N. Wagner, E. Klopocki, T. Higuchi, H. Duff, C. Maack, S. Ergün, B. Gerull (Würzburg; Calgary, CA)
(P178) Characterization of gender differences in a mouse model of Rbm20 cardiomyopathy
    D. Lennermann, M. van den Hoogenhof, M. Dewenter, C. Sticht, M. Krüger, J. Backs (Heidelberg, Mannheim, Köln)
(P179) LXR activation alters the cardiac lipid profile and reduces cardiac damage in an isoproterenol-induced cardiomyopathy model
    D. Ritter, A. Thiele, A. Blumrich, N. Beyhoff, K. Lüttges, E. Smeir, J. Kasch, J. Grune, O. J. Müller, R. Klopfleisch, C. Jäger, A. Foryst-Ludwig, U. Kintscher (Berlin, Kiel)