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Clin Res Cardiol (2021) DOI DOI https://doi.org/10.1007/s00392-021-01843-w |
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| Exercise prevents negative effects of aircraft noise via α1AMPK activation | ||
| M. Kvandova1, I. Schmal1, S. Kalinovic1, P. Stamm1, A. Daiber2, M. Oelze3, E. Schulz4, T. Münzel1, S. Kröller-Schön3 | ||
| 1Kardiologie 1, Zentrum für Kardiologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz; 2Labor für Molekulare Kardiologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz; 3Zentrum für Kardiologie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz; 4Klinik für Kardiologie, Allgemeines Krankenhaus Celle, Celle; | ||
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Background: Traffic (aircraft) noise exposure is
associated with cardiovascular oxidative stress mediated by activation of the
NADPH oxidase, uncoupling of endothelial nitric oxide synthase, and vascular
infiltration with inflammatory cells. Several studies highlighted the
protective effects of exercise via AMP-dependent protein kinase (AMPK) mediated
induction of beneficial signaling processes. In the present study, we
investigated the role of AMPK activation during voluntary exercise.
Methods and Results: Endothelial specific α1AMPK knockout (AMPKfl/fl x CdhCre+) and corresponding wild type (CdhCre+) mice were exposed to aircraft noise (maximum sound pressure level of 85 dB(A), average sound pressure level of 72 dB(A) for 4 last days of seven weeks of voluntary exercise. We could show that 4 days noise exposure lead to a significant endothelial dysfunction of aorta and a. mesenterica, which was associated with increased oxidative stress and endothelial nitric oxide synthase uncoupling. The voluntary exercise training for 7 weeks resulted in a marked improvement of endothelium-dependent relaxation and oxidative stress in wild type mice, while it had no protective effect in endothelial specific α1AMPK knockout mice. The beneficial effects of exercise training in the vasculature were accompanied by improvement of cerebral oxidative stress due to NADPH oxidases (NOX‐1, NOX‐2), which was also α1AMPK dependent. Conclusion: We here present novel data on exercise training as a protective strategy against negative effects of aircraft noise exposure by conferring AMPK activation. Our data suggest that exercise training might be an attractive mitigation strategy to protect the general population from noise-induced cardiovascular damage. Especially patients at high cardiovascular risk, with pre-existing cardio-metabolic disease or the elderly, could benefit from supervised exercise training to prevent additive cardio/cerebrovascular damage in response to transportation noise exposure. Support or Funding Information: German Research Foundation (Deutsche Forschungsgemeinschaft) DFG |
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https://dgk.org/kongress_programme/jt2021/aP1295.html |