Abstract 675 Association of the “Get with the Guidelines Heart Failure Risk Score” with Mortality in Patients Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair

Background
Reliable risk scores in patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) are lacking. Heart failure is common in these patients, and risk scores derived from heart failure populations might help stratify TMVR patients.

Methods
Consecutive patients from three Heart Centers undergoing TMVR were enrolled to investigate the association of the “Get with the Guidelines Heart Failure Risk Score” (comprising the variables systolic blood pressure, urea nitrogen, blood sodium, age, heart rate, race, history of COPD) with all-cause mortality.

Results
Among 815 patients with available data 177 patients died during a mean follow-up time of 365 days. Estimated one-year mortality by quartiles of the score (0-37; 38-42, 43-46 and more than 46 points) was 6%, 10%, 23% and 30%, respectively (p<0.001). Every increase of one score point was associated with a 9% increase in the hazard of mortality (95% CI 1.06-1.11%, p<0.001). The score was associated with long-term mortality independently of left ventricular ejection fraction, NYHA class and NTproBNP, and was equally predictive in primary and secondary mitral regurgitation.

Conclusion
The “Get with the Guidelines Heart Failure Risk Score” showed a strong association with mortality in patients undergoing TMVR with additive information beyond traditional risk factors, which can improve patients’ selection and effectivity of the procedure. Given the routinely available variables included in this score, application is easy and broadly possible.

Key words MitraClip, mortality, Get with the Guidelines Heart Failure Risk Score, heart failure

Clin Res Cardiol (2021) DOI DOI https://doi.org/10.1007/s00392-021-01843-w
Association of the “Get with the Guidelines Heart Failure Risk Score” with Mortality in Patients Undergoing Transcatheter Edge-to-Edge Mitral Valve Repair
C. Iliadis¹, M. Spieker², R. Kavsur³, C. Metze¹, P. Horn², R. Westenfeld², V. Tiyerili³, M. U. Becher³, M. Kelm², G. Nickenig³, S. Baldus⁴, R. Pfister¹
¹Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Köln; ²Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsklinikum Düsseldorf, Düsseldorf; ³Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Bonn; ⁴Klinik für Kardiologie, Angiologie, Pneumologie und Internistische Intensivmedizin, Herzzentrum der Universität zu Köln, Köln;
Background Reliable risk scores in patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) are lacking. Heart failure is common in these patients, and risk scores derived from heart failure populations might help stratify TMVR patients. Methods Consecutive patients from three Heart Centers undergoing TMVR were enrolled to investigate the association of the “Get with the Guidelines Heart Failure Risk Score” (comprising the variables systolic blood pressure, urea nitrogen, blood sodium, age, heart rate, race, history of COPD) with all-cause mortality. Results Among 815 patients with available data 177 patients died during a mean follow-up time of 365 days. Estimated one-year mortality by quartiles of the score (0-37; 38-42, 43-46 and more than 46 points) was 6%, 10%, 23% and 30%, respectively (p<0.001). Every increase of one score point was associated with a 9% increase in the hazard of mortality (95% CI 1.06-1.11%, p<0.001). The score was associated with long-term mortality independently of left ventricular ejection fraction, NYHA class and NTproBNP, and was equally predictive in primary and secondary mitral regurgitation. Conclusion The “Get with the Guidelines Heart Failure Risk Score” showed a strong association with mortality in patients undergoing TMVR with additive information beyond traditional risk factors, which can improve patients’ selection and effectivity of the procedure. Given the routinely available variables included in this score, application is easy and broadly possible. Key words MitraClip, mortality, Get with the Guidelines Heart Failure Risk Score, heart failure
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