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(V706) |
Transgenic LQT5, LQT2 and LQT2-5 rabbit models with decreased repolarization reserve for better prediction of drug induced pro-arrhythmic side-effects |
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T. Hornyik, A. Castiglione, G. Franke, S. Perez-Feliz, P. Major, L. Hiripi, G. Koren, Z. Bosze, A. Varro, M. Brunner, C. Bode, I. Baczko, K. Odening (Freiburg im Breisgau; Godollo, Szeged, HU; Providence, US) |
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Diskussion |
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(V707) |
Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation |
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S. Künzel, K. Sekeres, S. Kämmerer, P. Schlinkert, B. Binnewerg, C. Piorkowski, M. Mayr, K. Guan, M. Wagner, U. Ravens, S. Weber, A. El-Armouche (Dresden, Göttingen, Freiburg im Breisgau; London, UK) |
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Diskussion |
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(V708) |
Withdrawal of simulated obstructive sleep apnea partially reverses atrial arrhythmogenic substrate in rats |
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M. Hohl, B. Linz, A. Nickel, L. Lang, P. Boor, D. Wong, C. Maack, M. Böhm, P. Sanders, D. Linz (Homburg/Saar, Würzburg, Aachen; Adelaide, AU) |
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Diskussion |
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(V709) |
Piezo1 and BK stretch-activated channels in atrial fibrillation: remodelling and cross-talk |
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D. Jakob, A. Klesen, R. Emig, C. Schmidt, P. Kohl, U. Ravens, R. Peyronnet (Freiburg im Breisgau, Heidelberg) |
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Diskussion |
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(V710) |
Studying Brugada Syndrome with a SCN1b mutation using human-induced pluripotent stem cell-derived cardiomyocytes |
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I. El-Battrawy, J. Müller, Z. Zhao, L. Cyganek, H. Lan, X. Li, Q. Xu, M. Huang, Z. Liao, R. Zhong, B. Rudic, S. Albers, H. Dinkel, S. Lang, S. Diecke, W.-H. Zimmermann, J. Utikal, T. Wieland, M. Borggrefe, X. Zhou, I. Akin (Mannheim, Göttingen, Berlin) |
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Diskussion |
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(V711) |
A C-terminal variant alters biophysical properties of HCN4 channels acting as a genetic modifier of atrial fibrillation and structural heart disease |
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I. Weigl, P. Geschwill, C. Bruehl, A. Draguhn, M. Koenen, F. Sedaghat-Hamedani, B. Meder, D. Thomas, H. A. Katus, P. Schweizer (Heidelberg) |
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Diskussion |
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(V712) |
Selective inhibition of neuronal Na-channel NaV1.8 prevents cellular arrhythmogenesis in the human atrium |
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S. Pabel, S. Ahmad, P. Tirilomis, T. Stehle, N. Dybkova, P. Bengel, K. Streckfuß-Bömeke, G. Hasenfuß, L. S. Maier, S. T. Sossalla (Regensburg, Göttingen) |
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Diskussion |
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(V713) |
Human iPS cell-derived engineered heart tissue does not induce ventricular arrhythmias in a guinea pig cryo-injury model |
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A. P. Schwoerer, M. Röhl, K. Yorgan, B. Geertz, A. Hansen, F. Weinberger, S. Sehner, H. Ehmke, H. Reichenspurner, T. Eschenhagen, S. Pecha (Hamburg) |
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Diskussion |
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(V714) |
Arrhythmogenic consequences of the CaMKIIδ-dependent late sodium current and NaV1.8 in human heart failure |
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P. Tirilomis, S. Ahmad, N. Dybkova, P. Bengel, S. Pabel, L. S. Maier, K. Streckfuß-Bömeke, G. Hasenfuß, S. T. Sossalla (Göttingen, Regensburg) |
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Diskussion |