Clin Res Cardiol 107, Suppl 1, April 2018

Color paucity sign and basal leaflet thickening in the evaluation of subclinical leaflet thrombosis after TAVR: Correlation with high-resolution CT
L. Bäz1, M. Franz1, S. Möbius-Winkler1, U. Teichgräber2, P. C. Schulze3, A. Hamadanchi1
1Klinik für Innere Medizin I, Universitätsklinikum Jena, Jena; 2Institut für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Jena, Jena; 3Klinik für Innere Medizin I - Kardiologie, Universitätsklinikum Jena, Jena;


Background:
Clinical and subclinical thrombosis of leaflets following transcatheter aortic valve replacement (TAVR) has recently gained substantial attention. There is limited data on the role of echocardiography in the evaluation of subclinical valve thrombosis (SVT). Methods: A retrospective analysis was conducted of prospectively collected data in the Jenaer Aortenklappenregister (JAKR) at our institution. We included 124 consecutive patients who underwent TAVR since August 2016. All patients underwent routine echocardiographic evaluation before discharge and 4-8 weeks thereafter. High resolution 4D CT done for 84 patients and echocardiographic data were reviewed and correlated with CT. Mean Gradient of > 20 mmHg or more than 50 % increase in mean PG in transthoracic echocardiography was regarded as relevant stenosis. Results: The overall incidence of SVT was 10/124 (8.1 %; 8 Edward Sapien 3, 2 CoreValve Evolut R). Basal leaflet thickening was the most frequent finding in 80 % of cases and correlated very well with the CT findings. Further, color paucity sign had a 100 % correlation with CT (Fig. 1 A-D). Conclusion: Echocardiography shows a reasonable correlation to 4D-CT. Our data also suggest that echocardiographers should remain vigilant to these two subtle signs of valve thrombosis even when the gradients are within normal limits. This small study could serve as an impetus for further research and investigation in this field.





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