Clin Res Cardiol 107, Suppl 1, April 2018
Correlation of serum lipid profile with coronary CT angiography derived morphological and functional quantitative plaque markers
P. Kryeziu1, M. Rutsch1, C. Tesche2, D. Shuler3, T. Becher4, M. Behnes1, K. Stach1, M. Renker5, T. Henzler6, H. Haubenreisser6, S. Schoenberg6, C. Weiss7, M. Borggrefe1, U. J. Schoepf8, I. Akin1, D. Loßnitzer1, S. Baumann1
1I. Med Klinik - Kardiologie, Angiologie und Pneumologie und Intensivmedizin, Klinikum Mannheim GmbH,Universitätsklinikum, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim; 2Klinik für Kardiologie u. Internistische Intensivmedizin, Städt. Klinikum München GmbH, Herzzentrum München-Bogenhausen, München; 3Division of Cardiovascular Imaging, Department of Radiology and Radiological Science,, Medical University of South Carolina, Charleston, US; 4Laboratory of Molecular Metabolism, The Rockefeller University, New York, US; 5Abteilung für Kardiologie, Kerckhoff Klinik GmbH, Bad Nauheim; 6Institut für Klinische Radiologie und Nuklearmedizin, Klinikum Mannheim GmbH,Universitätsklinikum, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim; 7Abteilung für Medizinische Statistik, Biomathematik und Informationsverarbeitung, Universitätsmedizin Mannheim, Klinikum Mannheim GmbH,Universitätsklinikum, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim; 8Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, US;

Background: Recent advances in image quality of coronary CT angiography (cCTA) have allowed improved characterization of coronary plaques. Thus, we evaluated the correlation between morphological and functional quantitative plaque markers obtained by cCTA and serum lipid levels in patients with suspected coronary artery disease (CAD).

Materials and Methods: In this retrospective, single-centre study, we enrolled patients who underwent cCTA between January 2013 and February 2017. cCTA images were analyzed with a semi-automated plaque software prototype and various quantitative stenosis and morphological plaque markers, such as segment involvement score (SIS), segment stenosis score (SSS), remodeling Index (RI), presence of napkin-ring sign (NRS), total plaque volume (TPV), calcified and non-calcified plaque volume (CPV and NCPV) and plaque composition (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), low-density lipoprotein/high-density lipoprotein ratio (L/H ratio) and triglycerides (TG).

Results: A total of 119 patients (55 ±14 years, 66% male) were included in the study. Age (61 ±11 years vs. 52 ±14 years, p<0.0001), male gender (77% vs. 56%, p<0.0001) were higher in the plaque group. There were no differences regarding serum lipid levels between patients with or without detected plaques. After subcategorization for plaque composition, no significant differences regarding serum lipid levels could be observed. LDL serum levels >160 mg/dL correlated well with higher NCPV compared to patients with LDL between 100 and 160 mg/dL (112 vs. 27 mm³, p=0.0374). Other functional plaque markers were comparable between different patient groups.

Conclusion: Patients with suspected CAD and without lipid lowering medication did not show differences in their serum lipid levels depending on their respective extent and composition of plaques. High serum LDL levels correlated with a high non-calcified plaque volume.
http://www.abstractserver.de/dgk2018/jt/abstracts//P1055.htm