Clin Res Cardiol (2023). https://doi.org/10.1007/s00392-023-02302-4

Case report: Isolation of the superior vena cava using pulsed field ablation
D. Schaack1, S. Chen1, S. Bordignon2, S. Tohoku1, L. Urbanek3, B. Schmidt4, K. R. J. Chun1
1Medizinische Klinik III - CCB, Agaplesion Markus Krankenhaus, Frankfurt am Main; 2Medizinisches Versorgungszentrum, CCB am AGAPLESION BETHANIEN KRANKENHAUS, Frankfurt am Main; 3Station 24b Intensivstation, Agaplesion Markus Krankenhaus, Frankfurt am Main; 4Agaplesion Markus Krankenhaus, Frankfurt am Main;
Background: A 60-year-old female patient with symptomatic atrial fibrillation (EHRA III) which persisted for the last two months presented to our department for catheter ablation. Patient baseline data showed a CHA2DS2-VASc-Score of 1 (female patient), left atrial diameter of 39 mm and left ventricular ejection fraction of 72%. There was known sinus bradycardia of ~50 bpm. The patient did not take antiarrhythmic drugs.
Procedure: Pulmonary vein isolation (PVI) using a pentaspline pulsed field ablation (PFA) catheter (FARAWAVE) was performed according to a published standard protocol using 8 applications per pulmonary vein. After PVI and electrical cardioversion there was repeated reinduction of atrial fibrillation with the earliest activation observed in the right atrium. The FARAWAVE-catheter was then used to further map the trigger of these episodes and the superior vena cava (SVC) was found to be the location of the earliest activation. Using the basket-configuration of the catheter, PFA was performed at the SVC entrance (Figure 1), successfully isolating the SVC, and thus eliminating the trigger with only one application (Figure 2). No phrenic nerve palsy occurred. Immediately after the application, a junctional rhythm (40 bpm) was observed. It lasted for 30 minutes until sinus rhythm (50-60 bpm) reoccurred. The patient was discharged after two days in sinus rhythm without antiarrhythmic drugs.
Follow-up: 3-month follow-up showed no recurrence of atrial tachyarrhythmia without antiarrhythmic drugs. Further follow-up data will be assessed and reported.
Conclusion: The tissue selectivity of PFA allows a safe ablation of myocardium in proximity of susceptible extracardiac structures. We present a case of a successful SVC isolation without damage to the phrenic nerve. However, because of the extent of the lesions, attention must be paid to surrounding myocardial tissue. In our case, the temporary junctional rhythm after energy application could either be explained by potential sinus node damage or a prolonged autonomic response.

 
Figure 1


 
Figure 2

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