Clin Res Cardiol (2022). https://doi.org/10.1007/s00392-022-02087-y

Unexpected paradoxical embolization following catheter-directed thrombectomy with the Flow Triever system in a patient with pulmonary embolism – A case report

N. Uecker1, S. Baldus1, S. Rosenkranz1, A. Bunck2, T. Tichelbäcker1

1Klinik für Kardiologie, Angiologie, Pneumologie und Internistische Intensivmedizin, Herzzentrum der Universität zu Köln, Köln; 2Radiologie, Universität zu Köln, Köln;

Background: The optimal therapy for patients suffering from acute pulmonary embolism classified as intermediate-high-risk still needs to be identified. Catheter directed thrombectomy (CDTE) is a safe procedure to reduce thrombus burden immediately. The lack of big randomized trials is one reason, why CDT hast not yet received a clear recommendation in our guidelines. Herein we report an unexpected event in the course of a patient with PE treated with CDTE using the FlowTrieverTM system, the only FDA approved catheter system for this indication. Case Summary: a 57-year old male presented with dyspnea at the emergency department of our university hospital. The CT scan showed bilateral pulmonary embolism and ultrasound of the left lower limb revealed deep venous thrombosis. According to the current ESC guidelines he was classified intermediate-high risk. We performed bilateral catheter directed thrombectomy. On the first and third day post-intervention our patient presented neurological deficits. Whereas the first CT scan of the cerebrum remained normal, the CT-scan at day 3 showed a well demarcated embolic stroke. The transesophageal echocardiography revealed a patent foramen ovale (PFO) as the origin of paradoxical embolism and thus mechanism of the ischemic stroke. A control CT scan secondarily gave evidence to a mass in the left kidney, which further on was identified to be an ischemic lesion as well. Compliant to the current recommendations percutaneous PFO-closure was performed. Our patient recovered properly without any sequelae. Discussion: Whether the deep venous thrombosis is the source of embolization or the catheter directed retrieval of clots may have transported clot material to the right atrium which further on embolized systemically will remain unclear. Yet, we have to consider it as a potential complication in catheter directed treatment of pulmonary embolism in patients with a PFO.

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