Clin Res Cardiol 107, Suppl 1, April 2018

Short- and long-term incidence of stroke in Takotsubo syndrome

I. El-Battrawy1, T. Gietzen2, U. Ansari2, M. Behnes3, S. Lang3, X. Zhou3, M. Borggrefe1, I. Akin1

1I. Medizinische Klinik, Universitätsklinikum Mannheim, Mannheim; 2Klinikum Mannheim GmbH,Universitätsklinikum, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim; 3I. Med Klinik - Kardiologie, Angiologie und Pneumologie und Intensivmedizin, Klinikum Mannheim GmbH,Universitätsklinikum, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim;

Background Recently published data has elevated the impact of takotsubo syndrome (TTS) and its associated complications such as thromboemolic events, cardiogenic shock, arrhythmias and death consistently highlighting the same mortality rates in each scenario. Our study was established to compare the shorrt- and long-term incidence of stroke in TTS as compared to acute coronary syndrome (ACS). Methods and Results In our present analysis, we compared data from 138 TTS patients, included from 2003 to 2017, to 300 ACS patients included from 2007 to 2010. Our analysis revealed that the incidence of stroke was higher among TTS patients as compared to ACS patients over a mean follow-up period of 5 years. Interestingly, a lower number of TTS patients were treated with antiplatelet therapy at discharge (50% versus 100%; p=0.04), and the incidence of cancer in these patients was around 50% as compared to 0% in ACS patients with stroke (p=0.04). Conclusion The overall stroke event of TTS patients as compared to ACS patients is significantly increased acutely and over years after TTS events as well. TTS patients suffering of cancer should be considered a high-risk subgroup with respect to their increased stroke rate at short-term and long-term. As antiplatelet therapy may reduce major adverse cardiovascular events in TTS patients, it has to be determined in large registries ,whether and to what extent these results should lead to a generalized antiplatelet therapy in TTS patients.

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