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(V824) |
SMP-114, a CaMKII-Inhibitor Investigated in Phase II Trials for Rheumatoid Arthritis, Potently Reduces SR Ca2+-Leak and Cellular Arrhythmogenesis and Does Not Negatively Impact EC-Coupling |
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S. Neef, C. Mann, A. Zwenger, N. Dybkova, A. G. Rokita, J. Mustroph, M. A. Drzymalski, F. Schöndube, L. S. Maier (Regensburg, Göttingen) |
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Diskussion |
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(V825) |
Dantrolene reduces cellular arrhythmogenic triggers in human atrial fibrillation and heart failure cardiomyocytes |
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S. Pabel, N. Hartmann, J. Herting, T. H. Fischer, H. Schotola, N. Frey, G. Hasenfuß, S. T. Sossalla (Göttingen, Kiel) |
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Diskussion |
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(V826) |
The CaMKII inhibitor RA123456 prevents CaMKII-dependent ventricular and atrial arrhythmias and attenuates the development of heart failure in mice |
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J. Mustroph, C. M. Sag, M. Baier, S. Neef, B. Flörchinger, L. Rupprecht, C. Schmid, Y. Zausig, G. Bégis, V. Briand, A. J. Muslin, P. Janiak, P. Beauverger, L. S. Maier, S. Wagner (Regensburg; Chilly-Mazarin, FR; Cambridge, US) |
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Diskussion |
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(V827) |
Kinase/phosphatase balance regulates late INa dependent SR Ca2+ leak induction in ventricular myocardium |
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J. Eiringhaus, J. Herting, F. Schatter, M. Köhn, G. Hasenfuß, A. El-Armouche, S. T. Sossalla, T. H. Fischer (Göttingen, Heidelberg, Dresden) |
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Diskussion |
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(V828) |
Implications for the actions of cardiac glycosides in heart failure: Influence of increased Na+/Ca2+ exchanger expression on ouabain mediated effects on Ca2+ handling and repolarization |
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N. Bögeholz, P. Pauls, J. S. Schulte, G. Frommeyer, D. Dechering, U. Kirchhefer, G. Breithardt, F. U. Müller, L. Eckardt, C. Pott (Münster) |
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Diskussion |
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(V829) |
Transcriptional regulation of the L-type Ca2+ channel α1C-subunit contributes to the upregulation of the cardiac L-type Ca2+ current by corticosteroids and insulin |
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E. Rudakova, M. Wagner, T. Volk (Erlangen, Dresden) |
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Diskussion |